Destination

South America cruises from Vancouver

Nieuw Amsterdam's voyage down the Pacific side of the Americas in October 2027: California, Mexico, Central America, Ecuador, Peru and Chile, ending at San Antonio in Chile or carrying on by way of the Chilean fjords and the Falklands to Buenos Aires.

Our guide to repositioning cruises covers the one-way voyages to California, Asia, the Panama Canal and beyond each spring and autumn.

There are 2 such sailings on the board, running 26 to 41 nights, operated by Holland America Line aboard Nieuw Amsterdam. The lowest recorded starting fare is $3,409 per person, on the Thu, Oct 7, 2027 departure.

Ports of call

San Francisco (California)2 San Diego (California)2 Cabo San Lucas (Mexico)2 Huatulco (Mexico)2 Puerto Quetzal (Guatemala)2 Puntarenas (Costa Rica)2 Manta (Ecuador)2 Salaverry (Peru)2 Callao (Peru)2 General San Martin (Peru)2 Arica (Chile)2 Coquimbo (Chile)2 San Antonio (Chile)1 Puerto Montt (Chile)1 Puerto Chacabuco (Chile)1 Chilean Fjords (Chile, scenic cruising)1 Pio XI Glacier (Chile, scenic cruising)1 Punta Arenas (Chile)1 Stanley (Falkland Islands)1 Montevideo (Uruguay)1

Schedule last updated 2026-11-04 · 2 departures listed · Dates can change. Verify with the cruise line before booking.

Your South America options

All routes

The 2 departures below run 2 different routes, cheapest per night first.

Distinct itineraries available, cheapest per night first
Itinerary	Ship	Nights	Departures	From
41-Night South America Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean Fjords (Chile, scenic cruising) · Pio XI Glacier (Chile, scenic cruising) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay) Ends in Buenos Aires (Argentina) Next on Thu, Oct 7, 2027	Nieuw Amsterdam	41	1	$4,919$120 a night
26-Night South America Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) Ends in San Antonio (Chile) Next on Thu, Oct 7, 2027	Nieuw Amsterdam	26	1	$3,409$131 a night

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-11-04. Fares change often, so check the current price before you book.

Every departure by date

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South America sailings from the Port of Vancouver
Departs	Ship	Line	Nights	Itinerary & ports	From
Thu, Oct 7, 2027 ends Tue, Nov 2, 2027	Nieuw Amsterdam	Holland America Line	26	26-Night South America Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) Ends in San Antonio (Chile) Boards at Canada Place, West berth	from $3,409 $131 a night · per person interior, as of 2026-11-04 Lowest fare shown
Thu, Oct 7, 2027 ends Wed, Nov 17, 2027	Nieuw Amsterdam	Holland America Line	41	41-Night South America Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean Fjords (Chile, scenic cruising) · Pio XI Glacier (Chile, scenic cruising) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay) Ends in Buenos Aires (Argentina) Boards at Canada Place, West berth	from $4,919 $120 a night · per person interior, as of 2026-11-04

OCT
7
Thursday · 26 nights
26-Night South America
Nieuw Amsterdam · Holland America Line
Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile)
Ends in San Antonio (Chile)
Boards at Canada Place, West berth
Ends Tue, Nov 2, 2027 in San Antonio
Lowest fare shown
from $3,409 $131 a night · per person
interior, as of 2026-11-04
OCT
7
Thursday · 41 nights
41-Night South America
Nieuw Amsterdam · Holland America Line
Calls at San Francisco (California) · San Diego (California) · Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean Fjords (Chile, scenic cruising) · Pio XI Glacier (Chile, scenic cruising) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay)
Ends in Buenos Aires (Argentina)
Boards at Canada Place, West berth
Ends Wed, Nov 17, 2027 in Buenos Aires
from $4,919 $120 a night · per person
interior, as of 2026-11-04

By month

October 2027 2

Other destinations from Vancouver

Glacier Bay 323 sailings · from $631 Hubbard Glacier 136 sailings · from $674 Endicott Arm and Dawes Glacier 79 sailings · from $749 Tracy Arm 40 sailings · from $653 Other Alaska 89 sailings · from $419 Pacific coast 33 sailings · from $109 Hawaii 12 sailings · from $905 Japan and Asia 28 sailings · from $1,357 Panama Canal 5 sailings · from $2,068 South Pacific 2 sailings · from $2,609

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-11-04. Fares change often, so check the current price before you book.

South America from Vancouver: questions

How many South America cruises leave Vancouver?

2 South America cruises leave Vancouver, across 1 month, on 1 ship from Holland America Line.

How long are South America cruises from Vancouver?

From 26 to 41 nights: a 26-night trip on Nieuw Amsterdam leaving Thu, Oct 7, 2027 that ends in San Antonio and a 41-night trip on Nieuw Amsterdam leaving Thu, Oct 7, 2027 that ends in Buenos Aires.

Which ports do South America cruises from Vancouver call at?

The ports these 2 sailings call at most are San Francisco (2 sailings), San Diego (2 sailings), Cabo San Lucas (2 sailings), Huatulco (2 sailings), and Puerto Quetzal (2 sailings). Each sailing's own ports are in the list on this page.